DR. VEERAPPAN MUTHUKKARUPPAN
Advisor - Research

Dr. Veerappan Muthukkaruppan, after his Master's Degree in Zoology in 1957 at Annamalai University pursued higher studies for Ph.D. at the University of Wisconsin, Madison, USA on "The mouse lens induction and differentiation in vitro". The significance of his finding was illustrated as a cover picture in Investigative Ophthalmology in 1993, demonstrating that the anterior lens epithelium isolated from the embryonic and even adult lens has the ability to organize into a complete lens when the neural retinal stimulus is provided in culture.

He has worked as Professor of Immunology for over three decades in Madurai Kamaraj University wherein teaching at Master's level and Research at Ph.D. level were established in the field of Immunology. During this period, he has identified the origin of T and B lymphocytes in a reptile from which both mammals and birds evolved. He has elucidated the basic mechanism of immunological unresponsiveness in Leprosy. His major interest has been the development of candidate vaccine and diagnosis for murine typhoid using purified porine for which he also developed several monoclonal antibodies.

During his several visits to University of Wisconsin, as Visiting Professor he has developed a mouse corneal model to study the mechanism of angiogenesis induced by tumour, activated allogenic lymphocytes, and subsequently recombinant proteins like fibroblast and vascular endothelial growth factors. His model was also used to study the factors which inhibit angiogenesis.

As Founder-Director of Research, Dr. Muthukkaruppan has organized the research laboratory at Aravind Medical Research Foundation and contributed to the understanding of the pathogenic mechanism of diabetic retinopathy, corneal epithelial stem cells, Immunology of uveitis. At present, as Advisor he is interested in developing new programmes on the application of mesenchymal stem cells in regenerative medicine and genetics of retinoblastoma.

He is a Fellow of Indian Academy of Sciences (IASc), Fellow of Indian National Science Academy (INSA) and recipient of Ranbaxy Research Award for Basic Medical Sciences.
Email : muthu@aravind.org

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